文档介绍：扶正化瘀胶囊联合异甘草酸镁治疗失代偿期肝硬化患者的临床效果
[摘要] 目的 探討扶正化瘀胶囊联合异甘草酸镁治疗失代偿期肝硬化临床疗效及对肝功能、肝纤维化指标的影响。方法 选取2015年1月~2017年6月于唐山市传染病医院和华er treatment were observed. Results The effective rate was % in the case group, which was significantly higher than % in the control group, the difference was statistically significant (P < ). After treatment, compared with before treatment, The levels of total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), layer adhesion protein (LN), type Ⅳ collagen (CIV), hyaluronic acid (HA), and before collagen Ⅲ type (PCⅢ) were decreased, while the levels of albumin (ALB) and cholinesterase (CHE) were increased the difference was statistically significant (P < ). After treatment, liver function and liver fibrosis index TBIL, ALT, AST, LN, CIV, HA, PCⅢ levels decreased, levels of ALB and CHE increased in the two groups, the differences were statistically significant (P < ). After treatment, compared with the control group, levels of TBIL, ALT, AST, LN, CIV, HA, PCⅢ decreased, while the levels of ALB and CHE increased in the case group, the differences were statistically significant (P < ). Conclusion The effect of Fuzheng Huayu Capsules combined with Magnesium Isoserate in the treatment of chronic liver cirrhosis is significant. It can obviously improve the liver function and the degree of liver fibrosis, and it has a synergistic effect. [Key words] Fuzheng Huayu; Magnesium Isoglycyrrhizinate; Decompensated cirrhosis; Liver function; Liver fibrosis
肝脏是人体最重要的器官之一,其主要功能包含合成、排泄、解毒和生物转化等。肝硬化是临床常见的慢性肝病,通常由一种或多种原因引起,其组织学特征表现为肝脏弥漫性纤维化、假小叶和再生结节形成[1]。乙型肝炎病毒(HBV)感染和酒精性肝病是引起我国肝硬化最常见的病因[2]。失代偿期肝硬化患者可出现上消化道出血、腹水、感染、黄疸等各种并发症,并可因肝功能衰竭死亡。本研究采用扶正化瘀联合异甘草酸镁治疗失代偿期肝硬化患者,取得较好效果,现报道如下:
1 资料与方法
一般资料
选取2015年1月~2017年6月于河北省唐山市传染病医院(以下简称“我院”)和华北理工大学附属医院住院的失代偿期肝硬化患者120例,按照随机数字表法,随机分为对照组和病例组,每组各60例。其中男89例,女31例;乙型肝炎肝硬化62例,酒精性肝硬化53例,药物性肝硬化5例。两组患者性别、年龄、肝硬化类型、肝功能分级等一般资料比较差异无统计学意义(P > ),具有可比性。本研究经我院医学伦理委员