文档介绍：Taxol
Outline
Discovery and history of Taxol
Source of Taxol
Taxol Industrialization
In 1967, Taxol was disc
Taxol
Outline
Discovery and history of Taxol
Source of Taxol
Taxol Industrialization
In 1967, Taxol was discovered by Dr. Monroe E. Wall and Dr. Mansukh C. Wani at Research Triangle Institute (RTI) of North Carolina, USA.
Later ,they isolated the compound from the Pacific yew tree, and noted its antitumor activity in a broad range of solid tumors.
In 1970, the two RTI scientists determined the structure of taxol through X-ray crystallization diffraction analysis .
Discovery and history of Taxol
In 1979, Susan Horwitz of Albert Einstein Medical College reported that Taxol has a unique mechanism of action .
tubulin
microtubules
mitosis
co-polymerize
help
Taxol
Discovery and history of Taxol
Taxol
In 1989, Johns Hopkins University reported the striking clinical results with advanced ovarian cancer in The Annals of Internal Medicine.
In the same year, NCI determined to commercialize the drug.
In 1991 Dr. Samuel Broder, then director of NCI, hailed Taxol as the most important new cancer drug in the next 15 years.
In December 1992 the FDA approved Taxol for refractory ovarian cancer. Later, it was approved for breast cancer.
Discovery and history of Taxol
Today
ovarian cancer
breast cancer
non-small-cell lung cancer
Karposi's sarcoma
a variety of other cancers (potential antitumor activities )
The information for patients and physicians about Taxol's use and side effects is available from the FDA.
Discovery and history of Taxol
Outline
Discovery and history of Taxol
Source of Taxol
Taxol Industrialization
Very expensive, about 4,800 dollars for one gram.
Yew trees grow very slowly and contain only a small amount of taxol.
Environmental problems.
Source of Taxol
Dongbei Yew :Evergreen tree
Source of Taxol
Media Yew :the first choice for taxol extraction which approved by FDA.
Source of Taxol