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1162 现代预防医学 2006 年第 33 卷第 2 期 Modern Preventive Medicine , 2006 , Vol 33 , No 2
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1 壳聚糖的毒性研究1
程东1 , 韩晓英2 , 冯宁1 , 张天亮1 , 李慧1
[摘要] 目的: 研究壳聚糖的毒性。方法: 小鼠急性毒性试验、Ames 试验、小鼠骨髓嗜多染红细胞微核试验、小
鼠精子畸形试验、大鼠 30 d 喂养试验。结果: 壳聚糖属实际无毒物质; Ames 试验、微核试验和精子畸形试验结果均为阴
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性; 大鼠 30 d 喂养试验结果显示该样品 30 d 喂养对大鼠各项观察指标未见毒性作用。结论: 在本次实验条件下, 壳聚糖
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为无毒物质, 未显示有遗传毒性和亚急性毒性作用。
[关键词] 壳聚糖; 急性毒性试验; 遗传毒性试验; 大鼠 30 d 喂养试验
[中图分类号] R15 [文献标识码] A [文章编号] 1003 - 8507 (2006) 02 - 0162 - 03
STUDY ON TOXICITY OF CHITOSAN. CHENG Dong , HAN Xiao ying , FENG Ning , et al. Department of Toxicology , Shandong
Center for Disease Control and Prevention , Jinan , 250014.
Abstract : Objective : To study the toxicity of chitosan. Methods : Acute toxicity test of mice , Ames test , micronucleus test of bone
marrow PCE cell in mice , sperm shape abnormality test of mice , thirty days feeding study were done. Results : Chitosan was a substance
with no toxicity. The results of ic toxicity test were all negative , including Ames test , micronucleus test and sperm shape abnormality
test. The results of thirty days feeding study was also negative. Conclusion : Chitosan is a substance with no toxicity and have no ic tox
icity and subacute toxicity under the condition of this test.
Key words : Chitosan ; Acute toxicity test ; ic toxicity ; Thirty days feed