文档介绍：Journal of Biomaterials and Nanobiotechnology, 2011, 2, 216-225
doi:.23027 Published Online July 2011 (rnal/jbnb)
Biodegradable haride Gels for Skin
Scaffolds
Stephen J. Juris1, Anja Mueller1, Brian T. L. Smith1, Samantha Johnston1, Robert Walker1,
Robert D. Kross2
1Central Michigan University, Mt. Pleasant, USA; 2Kross Link Labs, Bellmore, USA.
Email: ******@, ******@
Received March 2nd, 2011; revised May 2nd 2011; accepted June 10th, 2011.
ABSTRACT
A variety of skin substitutes are used in the treatment of full-thickness burns. Substitutes made from skin can harbor
latent viruses, and artificial skin grafts can heal with extensive scarring, failing to regenerate structures such as glands,
nerves, and hair follicles. Biodegradable and patible hydrogels, however, rarely mimic the strength of the epi-
dermis. Therefore, novel and practical skin scaffold materials remain to be developed. harides form hydrogels
with predicted inherent patibility. This paper describes the preparation and patibility of unique hydrogel
skin scaffolds from plant-extracted haride mixtures of specific sources, types, and molecular weight fractions.
These hydrogels have a range of mechanical and degradation properties with the potential to fulfill the multiple, di-
verse functions of artificial skin, including protection, compatibility with different cell types, biodegradation, and re-
lease of needed signals for cell growth and wound healing.
Keywords: Hydrogel, harides, Skin Scaffold
1. Introduction limited patible and biodegradable materials avai-
lable. Hydrogels have been used as an alternate artificial
The skin is the an in the body and serves many
skin, because good hydration is the most important ex-
important functions, such as protection against infection,
ternal factor responsible for optimal wound healing [11-
immune surveillance, perception of touch, and tempera-
14], as water i