文档介绍：Liang et al. BioMedical Engineering OnLine 2011, 10:84
ring-/content/10/1/84
RESEARCH Open Access
putational model study of the influence of
the anatomy of the circle of willis on cerebral
hyperperfusion following carotid artery surgery
Fuyou Liang1*, Kazuaki Fukasaku2, Hao Liu3 and Shu Takagi1,4
* Correspondence: ******@ Abstract
1Computational Science Research
Program, RIKEN, Wako, Saitama, Background: Cerebral hyperperfusion syndrome develops in a small subset of
Japan
Full list of author information is patients following carotid artery surgery (CAS) performed to treat severe carotid
available at the end of the article artery stenosis. This syndrome has been found to have a close correlation with
cerebral hyperperfusion occurring after CAS. The purpose of this study is to
investigate whether and how the anatomy of the Circle of Willis (CoW) of the
cerebral circulation influences post-CAS cerebral hyperperfusion.
Methods: putational model of the cerebral circulation coupled with the
global cardiovascular system has been developed to investigate hemodynamic
events associated with CAS. Nine topological structures of the CoW were
investigated bination with various distribution patterns of stenosis in the
feeding arteries of the cerebral circulation.
Results: The occurrence of post-CAS cerebral hyperperfusion was predicted for the
CoW str