文档介绍：首参颗粒对颈动脉硬化患者端粒、端粒酶的影响
楼丹飞1,申定珠2,陈川2*,李越华1,沈睿1, 基金项目:国家自然科学基金((81202664),上海市卫生局局级科研项目(2010225, 20114047),上海市卫生局中医药科研基金项目(2010L046A)
作者单位:1上海市中医医院,上海市芷江中路274号(上海 200071);2上海市中医老年医学研究所,上海市徐汇区襄阳南路558号4楼(上海 200031)
*通讯作者:陈川(1963-),男,浙江温州人,主任医师,硕士研究生导师,主要从事中医老年病研究。
陈久林2,邢三丽2,刘特2
Effects of Chinese herbal medicine Shoushen Granule on telomere、telomerase on patients with carotid atherosclerosis
Danfei Lou1,Dingzhu Shen2,Chuan Chen2*,Yuehua Li1,Rui Shen1,Jiulin Chen2,Shanli Xing2,Te Liu2
1 Shanghai Municiple Hospital of TCM,Shanghai,200071
2Shanghai Geriatric Institute of Chinese Medicine,Shanghai,200032
摘要:目的:观察补肾中药复方首参颗粒对颈动脉粥样硬化(atherosclerosis, AS)患者外周血端粒、端粒酶的影响,初步探讨其作用机制。方法:选取156例颈动脉粥样硬化患者,随机分为治疗组83例和对照组73例,对照组口服普伐他汀,治疗组服用首参颗粒,疗程均为6个月。于治疗前后分别采用实时荧光定量PCR(Real-Time Quantitative Polymerase Chain Reaction , RQ PCR)方法检测外周血端粒、端粒酶的变化。结果:中药组治疗6月后端粒长度同治疗前比较均有显著性差异(P<),西药组治疗6月后端粒长度同治疗前比较有显著性差异(P<), 中药组和西药组比较无统计学差异(P>)。两组治疗6个月后端粒酶活性均较治疗前提高(P<), 中药组和西药组比较无统计学差异(P>)。结论:调控颈动脉粥样硬化患者外周血端粒长度及端粒酶活性可能是补肾中药复方首参颗粒有效作用机制之一。
关键词:首参颗粒;颈动脉粥样硬化;端粒;端粒酶
Abstract: Objective: To investigate the effect of Invigorating kidney pound Shoushen Granule on peripheral blood telomere, telomerase in patients with carotid atherosclerosis (AS) .Methods: 156 patients with carotid atherosclerosis, 83 cases were randomly divided into treatment group
, 73 cases were control group, the control gro