文档介绍：《化学通报》在线预览版
生物检材中氯胺酮及其代谢物的分析方法研究进展
张月琴* 叶能胜谷学新
(首都师范大学化学系北京 100037)
摘要综述了生物检材中氯胺酮及其代谢物分析技术的进展,评述了液相萃取、固相萃取、固相微萃取、顶空固
相微萃取、微波辅助萃取等技术在分析中的应用,以及薄层色谱、气相色谱、高效液相色谱、电泳及其联用检测技术、
酶联免疫分析技术和太赫兹时域光谱等检测技术在分析生物检材中氯胺酮的优势和局限性,并展望了该领域研究的发展
趋势。
关键词氯胺酮代谢物生物检材
Progress in Analysis Method of Ketamine and Metabolites in Biological Samples
Zhang Yueqin , Ye Nengsheng , Gu Xuexin
(Department of Chemistry , Capital Normal University, Beijing 100037)
Abstract Analytical techniques for ketamine and metabolites and their recent development were reviewed. The application of
sample pre-treatment techniques such as liquid-liquid extraction, solid-phase extraction, solid phase micro-extraction, headspace
solid phase microextraction, and microwave assisted extraction were discussed. The advantages and limitations of thin-layer
chromatography, gas chromatography, high-performance liquid chromatography, capillary electrophoresis and their conjunction
with mass spectrometry, ELISA and Terahertz time-domain spectroscopy techniques were summarized. The trend for the future
research in this field was also briefly prospected.
Keywords Ketamine, Metabolites, Biological samples
近年来,氯胺酮(ketamine ,俗称 K 粉)的滥用现象日益严重,并有愈演愈烈之势,特别流行于舞
厅等娱乐场所,对社会治安和经济建设造成极大危害。滥用毒品倾向呈现年轻化、男女平均化且女性滥
用者的比例上升和用药多元化的趋势,由滥用鸦片类药物发展到多种药物的滥用。调查发现,毒品滥用
中 K 粉比例达 20%以上,短期可使语言迷糊,引起幻觉,长期可使人记忆力衰退及认知能力障碍,导致