文档介绍：DMA(二甲基乙酰胺,N,N-dimethylacetamine)
《药用辅料手册》(四川出版社)
作用与用途:本品在药剂中用作溶剂和助溶剂。做溶剂用于溶解塑料、树脂等高分子化合物成膜、成囊材料,以制备膜剂、微囊剂等。做助溶剂多用于制备注射剂。
安全性:本品有一定毒性,小白鼠腹腔注射,。本品有溶血左右,当浓度小于10%时,%氯化钠有一定阻止效果。
Martindala:
Adverse Effects and Precautions
As for Dimethylformamide, although a disulfiram-like reaction with alcohol has not been reported. A review1 of the toxicology of dimethylacetamide with reference to its use as a vehicle for antineoplastics.
1. Kim S-N. Preclinical toxicology and pharmacology of dimethylacetamide, with clinical notes. Drug Metab Rev 1988; 19: 345–68. PubMed
Handling.
Suitable precautions should be taken to avoid skin contact with dimethylacetamide as it can rate skin and produce systemic toxicity.
Uses
Dimethylacetamide is used as an industrial and pharmaceutical solvent.
FDA IIG limit:
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Search Results for: "dimethylacetamide"
INACTIVE
INGREDIENT
ROUTE;DOSAGE FORM
CAS
NUMBER
UNII
MAXIMUM
POTENCY
N,N-DIMETHYLACETAMIDE
INTRAMUSCULAR; INJECTION
127195
JCV5VDB3HY
N,N-DIMETHYLACETAMIDE
INTRAVENOUS; INJECTION
127195
JCV5VDB3HY
%
N,N-DIMETHYLACETAMIDE
IV(INFUSION); INJECTION
127195
JCV5VDB3HY
DMSO(Dimethyl Sulfoxide 二甲亚砜)
《药用辅料手册》(四川出版社)
作用与用途:作透皮促进剂、溶剂和防冻剂。
安全性:本品无毒安全,吸收后主要以原形从尿排出,少部分被氧化成二甲基碸由尿排出。本品高浓度有时产生灼烧不适感,或瘙痒、红斑,有时会引起恶心、呕吐等全身反应。
《药用辅料手册》(化工出版社)
作用与用途:溶剂、局部穿透促渗剂
安全性:具有局部毒性作