文档介绍：大理学院药学院药理学教研室
彭芳教案
课程:药理学
教材:李端主编《药理学》(第五版,人民卫生出版社,2003)
杨宝峰《药理学》(第六版,人民卫生出版社, 2003)
授课对象:04级药学本科1~2班
授课时间:2006年9月25日-10月16日
教师:彭芳
职称:教授
参考书籍:
杨藻宸:《医用药理学》
杨宝峰《药理学》(规划教材,北京大学出版社,2003)
中枢药理(12学时)
教学内容
授课学时
授课时间
镇静催眠药(双语教学)
9月25日
抗癫痫药和抗惊厥药
9月25日
治疗中枢神经系统退行性疾病药
局部麻醉药
9月28日
抗精神失常药
10月9日
镇痛药
10月12日
解热镇痛抗炎药(双语教学)
10月16日
药学院药理学教研室教案
 Chapter 12 Sedative-Hypnotics
[Aims]:
understand the clasification and representative drugs of Sedative-Hypnotic Drugs. the pharmacological action and clinical application of benzodiazepines.
the traits of barbiturates.
[Teaching Contents and learning time distribution]:
: 55 minute
2. Barbiturates:20 minute
other sedative-hypnotics: 5 minute
[Assistant Teaching]: make use of projector
[Vocabulary list]: benzodiazpine; diazepam
[Review]:
1. Try to relate the action and uses of benzodiazepines.
2. What is advantage of benzodiazepines for hypnotic action pare with
barbitals?
[Teaching contents]:
Ⅰ.General Introduction
A. Definition
Hypnotics are drugs used to produce drowsiness and sleep,while sedatives are used to calm anxious anxious and restless patients.
B. Two phases of sleep
1. Rapid eye movement sleep (REM, paradoxical sleep)--20 min in each run
 
-rapid eye movement sleep (NREM, orthodox sleep)
--90 min in each run
--divided to four stages
--stage 3 and 4-- slow wave sleep, somnambulism and night terrors
C. Physiological sleep consists of 4-5 cycles of alternative REM and NREM
 
 
 
 
Ⅱ.Benzodiazepines (BZD)
A. Classification
1. Short-acting (t1/2<5hrs): triazolam, midazolam etc  
2. Intermediate-acting (t1/2= 5-15hrs):   lorazepam, oxazepam etc
3. Long-acting (  t1/2>15hrs): diazepam, flurazepam etc
B. ics
1. Intramuscular injection unreliable, given orally
2. Most metabolisms in liver
3. Some metabolites half-lives greater than the parent drugs
 
 
C. Pharmac