多肽合成,定制多肽,多肽文库,多肽合成技术,LifeTein Service Overview.pdf

文档介绍：1
Outline
Market & Technology Trends

LifeTein Technology Portfolio

LifeTein Services
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Synthetic Therapeutic Peptides
More than 60 synthetic therapeutic peptides under 50 amino acids in
size have reached the pharmaceutical market as APIs or generics. 3
Chemical Optimization
Drug Discovery Today Volume 15, Numbers 1/2 January 2010
Strategies for Lead Peptide Optimization 4
Technology Trends
Microwave Synthesis

Using Nitroalkanes as Acyl Anion
Equivalents
finder/
Green Chemistry for Synthesis
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LifeTein Technology Portfolio
PeptideSynTM Platform

Provides high-yield
peptide synthesis

Combines SPPS and
LPPS for the highest
synthesis ess rate
possible

Ensures shorter
turnaround

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LifeTein Technology Portfolio
PeptideSynTM Ligation

Synthesizes long
peptides (up to 120
amino acids)

Ensures high yield and
short turnaround

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LifeTein Technology Portfolio
A: H-MEDSTYYKASKGC-NH2
B: H-MEDST(PTyr)YKASKGC-NH2
C: H-PKYLQNTLKLATGMRNVPEKQTT-OH
D: H-MEDSTYYKASKGC-NH2
E: H-MEDST(PTyr)YKASKGC-NH2
F: H-PKYLQNTLKLATGMRNVPEKQTT-OH

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LifeTein Services

Custom Peptide Synthesis Service

Custom Peptide Library Synthesis Service

Custom Polyclonal Antibody Service

Custom Monoclonal Antibody Service
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LifeTein Services
Advantages of PeptideSynTM Technology

Increases yields and reduces costs

Shortens production cycle

Combines the advantages of both solid and solution phase methods

Can scale up projects rapidly to over 100 kg

Avoids solubility problems for long segments in solution phase
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