文档介绍：Coronary Artery Atherosclerotic Heart Disease (Angina and Myocardial infarction)
Prof. Jing HUANG .
Department of cardiology
The Second Hospital of
Chongqing Medical University
Chongqing 400010
Epidemiology of Atherosclerosis Diseases
Leading cause of morbidity and mortality in world wide
The death rate of atherosclerosis is increase rapidly in the Third World
Fortunately, The progression of atherosclerosis may be slowed even reversed with appropriate lifestyle and drug interventions
Risk Factors:
Aging
The adoption of a diet high in fat, calories and cholesterol
physical inactivity (as a potato on sofa)
blood lipid abnormalities low-density lipoprotein cholesterol↑
cigarette smoking
Suffer from hypertension and diabetes mellitus
Genic factors (heredity)
ic factor
alcohol intaking
pathogenesis
●Lipid hypothesis
(cholesterol into artery wall)
●Platelet aggregate and thrombus formation hypothesis
(trigged by endothelial injure)
●Smooth cell clone hypothesis
● Inflammation hypothesis
damaged from endothelial dysfunction
第Ⅰ期初始病变(initial lesion)
第Ⅱ期脂质条纹期(fatty streak)
第Ⅲ期粥样斑块前期(pre-atheroma)
第Ⅳ期粥样斑块期(atheroma)
第Ⅴ期纤维斑块期(fibroatheroma)
第Ⅵ期 plicated lesions )
Atherosclerosis in coronary artery
Definition
Coronary artery disease (CAD) results from progressive blockage of the coronary vessels by arteriosclerosis.
Clinical syndromes result from an imbalance of oxygen supply and demand inadequate myocardial perfusion to meet metabolic demand (myocardial ischemia).
Plaque hemorrhage or rupture with thrombosis are responsible for most ischemia syndromes.
Anatomy