文档介绍：独活寄生汤对兔膝骨性关节炎关节液白细胞介素-1和肿瘤坏死因子的影响
作者作者单位
刘英杰华北煤炭医学院附属医院骨科,河北唐山 063000
马利杰华北煤炭医学院附属医院骨科,河北唐山 063000
王相利华北煤炭医学院附属医院骨科,河北唐山 063000
基金项目:河北省中医药管理局科研课题(计划项目编号:2004048)
Effect of Duhuojisheng decoction on IL-1 and TNF from synovial fluid in rabbit with osteoarthritis
LIU Yingjie, MA Lijie, WANG Xiangli
Department of Orthopaedics, Hospital Affiliated to Northern China Coal Medical College, Hebei, Tangshan 063000
【Abstract】Objective To observe the effect of Duhuojisheng decoction on the expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis. Methods 24 rabbits were randomly divided into control and treatment groups. There were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment. Results There were expression of IL-1 and TNF from synovial fluid a week after treatment. Following weeks expression of IL-1 and TNF raised in control group. In 3 weeks peak appeared. Expression of IL-1 a
nd TNF raised in treatment group pared with those in control group (P<, P<). Conclusion Duhuojisheng decoction can depress the expression of IL-1 an