文档介绍：盐酸氨溴索联合N―乙酰半胱氨酸治疗慢性支气管炎的临床疗效研究
【摘要】目的研究盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效。方法研究纳入98例确诊的慢性支气管炎患者, 其中男性75例, 女性23例。将患者随机分为单纯盐酸氨溴索治疗的对照组(49例)和联合了N-乙酰半胱氨酸治疗的观察组(49例)。此外, 两组均给予抗炎等常规治疗。按上述方案治疗6个月后, 比较两组的治疗效果, 用力肺活量(FVC)、FEV1/预计值(%)、FEV1/FVC(%)等肺功能指标以及生活质量评分在治疗前后的改变。结果两组均能在消除咳嗽、咳痰、喘息等症状方面取得良好疗效, 在影像学检查指标方面也均达到预期的治疗效果。但联合N-乙酰半胱氨酸治疗的观察组总体有效率更高, 与对照组相比差异具有统计学意义(P<), 此外观察组患者的肺功能指标在治疗后优于对照组(P<), 生活质量评分也高于对照组(P<)。结论盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效较优, 可以在临床中推广。
【关键词】慢性支气管炎; 盐酸氨溴索;N-乙酰半胱氨酸;疗效
【Abstract】 Objective To investigate the effect of ambroxol bined with N-acetylcysteine in the treating of chronic bronchitis. Methods 98 cases (male n=75, female n=24) with chronic brochitis were divided into the control group (n=49) and the observati
on group (n=49) randomly. All groups received basic treatment such as anti-inflammatory therapy. Moreover, in the control group patients were also treated with f ambroxol hydrochloride and in the observation group fambroxol hydrochloride were used with N-acetylcysteine. Results All group had a good effect on relieving cough, sputum and other symptoms. Nevertheless in the observation group, the total effective rate was higher than that in the control group (P<). Compared with control group, observation group showed greater improvement in pulmonary function and life quality. Conclusion The effect of ambroxol bined with N-acetylcysteine in the treat