抗心率失常药物.ppt

文档介绍：抗心律失常药Antiarrhythmics?Originationsite:Supraventricular:atrial,atrioventricularnodalVentricular:?Rhythm:快速型(tachyarrhythmias):早搏,心动过速,颤动,扑动prematurebeats,tachycardia,fibrillation,flutter缓慢型(bradyarrhythmias):心动过缓,传导阻滞bradycardia, DrugTherapy?bradyarrhythmias-?心脏的药(Atrop, Isop.)?tachyarrhythmias- Basis ofAPmv300-70-900相Na+内流1相K+外流2相K+外流,Ca2+内流3相K+外流4相APDFig. 23-1动作电位时相与跨膜离子流的关系。 responsecellsSlow RC?,心室肌(固有C)窦房结,房室结(自律C)房室特殊传导系统(自律C)? and slowelectricalactivitiesFRCSRC?0相快Na+内流为主慢Ca2+内流?4相Na+内流?,Ca2+内流?,K+外流?K+外流??4相自动去极化速率快,达阈电位时间短,自律性高