基于莫诺苷转化的山茱萸环烯醚萜苷提取工艺研究.pdf

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第 17 卷第 9 期中国实验方剂学杂志 Vol. 17,No. 9
2011 年 5 月 Chinese Journal of Experimental Traditional Medical Formulae May,2011
DOI: CNKI:11-3495/
基于莫诺苷转化的山茱萸环烯醚萜苷提取工艺研究
٭周洪亮,常星洁1 ,陈武1 ,刘志辉2
(1. 南京中医药大学,南京 210029;2. 江苏省中医院,南京 210036)
[摘要] 目的:基于莫诺苷转化现象研究山茱萸环烯醚萜苷的提取工艺。方法:采用正交试验法,优选山茱萸环烯醚萜苷
提取工艺。结果:山茱萸中环烯醚萜苷的最佳提取工艺为:以水做提取溶剂,加 10 倍量水,提取 3 次,每次 80 min,莫诺苷转移
率为 145% ,马钱苷为 92% 。结论:优选所得山茱萸提取工艺稳定、合理,可大量提高莫诺苷的提取量。
[关键词] 山茱萸;莫诺苷;马钱苷;转化;提取工艺
[中图分类号] R283. 6 [文献标识码] A [文章编号] 1005-9903(2011)09-0-0
Study on Extr acting Technology of Ir idoid Glycoside fr om Cor ni Fr uctus Based
on Tr ansfor mation of Mor r oniside
ZHOU Hong-liang1 ,CHANG Xing-jie1 ,CHEN Wu1 ,LIU Zhi-hui2
﹙1. NanJing university of TCM,Nanjing 210029;2. hospital of TCM of Jiangsu province,Nanjin 210036,China﹚
[Abstr act ] Objective:Study on extracting technology of iridoid glycoside from Corni fructus based on
transformation of morroniside. Method:The optimal conditions for extracting iridoid glycoside from Corni fructus
were studied by orthogonal design. Result:The optimal conditions of refluxing method were as follows:water was
used to extract for 3 times and ten times volume of solvent was used to extract for 80 minutes for each time,
morroniside transformationrate was 145% ,loganin was 92% . Conclusion:The optimum extraction processes are