文档介绍：424 食品与药品 Food and Drug 2011年第13卷第11期
双黄胶囊真空带式干燥工艺研究
张淹1,田守生1,郝向慧1,王树仁2,史兆松1
(1. 山东东阿阿胶股份有限公司,山东聊城 252201;2. 山东阿华生物药业有限公司,山东聊城52000)
摘要:目的研究确定双黄胶囊真空带式干燥的最佳工艺条件。方法采用正交设计和多指标综合评分法,以双黄胶囊内
容物干燥后的小檗碱含量、水分和干燥速率为考察指标,考察影响双黄胶囊内容物真空带式干燥过程的主要因素。结果
(20 ℃)时,真空带式干燥的最佳工艺条件:履带速度15 cm/min,进料速度25 L/h,干燥温度
的3个加热区温度分别为85,95,85℃。结论采用真空带式干燥工艺生产的双黄胶囊,水分符合胶囊剂含水量的标准,且
干燥速率和指标性成分的保留率均较好。
关键词:双黄胶囊;真空带式干燥;正交设计;多指标综合评分法
中图分类号:R971+.3 文献标识码:A 文章编号:1672-979X(2011)11-0424-03
Study on Vacuum Belt Drying Process of Shuanghuang Capsules
ZHANG Yan1, TIAN Shou-sheng1, HAO Xiang-hui1, WANG Shu-ren2, SHI Zhao-song1
(1. Shandong Dongeejiao Co.,Ltd., Liaocheng 252201, China; 2. Shandong E-Hua Biotech Pharmaceutical Co.,Ltd.,
Liaocheng 252201, China)
Abstract: Objective To investigate the optimum conditions of the vacuum belt drying process of Shuanghuang
Capsules. Methods The process was studied by orthogonal design and multi-index grading method. The contents
of Berberine Hydrochloride, water remained in the dried product and drying rate of Shuanghuang Capsules were
assessed, to investigate which are the leading factors for the vacuum belt drying process. Results The optimum process
was achieved when the relative density of Shuanghuang Capsules fluidextract was at (20℃). The conditions were:
the belt speed was 15cm/min, the feeding speed was 25L/h, the temperature of