文档介绍：食品与药品 Food and Drug 2011年第13卷第07期 249
β-环糊精包合罗勒挥发油的工艺研究
徐瑞超,董自亮,舒杨
(成都中医药大学药学院,四川成都 611137)
摘要:目的筛选β-环糊精(β-CD)包合罗勒挥发油的最佳工艺。方法采用响应面分析试验,以挥发油包合率、包合物
产率为主要筛选指标,选出制备罗勒油-β-CD包合物的最佳包合条件;采用显微镜法、薄层色谱法和紫外分光光度法验证
了包合物的形成。结果最佳包合工艺为罗勒油-β-CD为1︰(w/w),包合时间72 min, ℃。结论采用响
应面法优化得出的包合工艺合理,包合率高。
关键词:罗勒;挥发油:包合;响应面分析法
中图分类号:R972 文献标识码:A 文章编号:1672-979X(2011)07-0249-05
Study on β-Cyclodextrin Inclusion Technique for Volatile Oils in Ocimum basilicum
XU Rui-chao, DONG Zi-liang, SHU Yang
(School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China)
Abstract: Objective To screen the β-cyclodextrin(β-CD)inclusion technique for volatile oils in Ocimum basilicum.
Methods With the inclusion rate of volatile oils and the yield of plex as the main screening indexes, the
optimal inclusion conditions were defined by the response surface analysis. The formation of plex was
verified by microscopy, TLC and UV. Results The optimal inclusion technique was as follows: the ratio of volatile oils
to β-cyclodextrin of 1︰(w/w), stirring for 72 min at ℃. Conclusion The inclusion technique optimized by
the response surface analysis can be reasonable with high inclusion rate.
Key Words: Ocimum basilicum; volatile oil; inclusion; response surface analysis
罗勒(Ocimum basilicum L.)为唇形科罗勒属植效,给其固体制剂的制备带来诸多不便。将罗勒挥发
物,又名九层塔、甜罗勒,主要分布于东半球热带地油与β-CD制