文档介绍：第24卷第9期生命科学 Vol. 24, No. 9
2012年9月 Chinese Bulletin of Life Sciences Sep., 2012
文章编号:1004-0374(2012)09-0997-15
海洋真菌来源的抗菌活性物质研究:方法与进展
尚卓1,2,王斌贵1*
(1 中国科学院海洋研究所,实验海洋生物学重点实验室,青岛 266071;2 中国科学院研究生院,北京 100039)
摘要:病原微生物的耐药性已严重威胁到人类的健康,因此,研发结构新颖、活性显著的新型抗生素已
迫在眉睫。海洋独特的生态环境孕育了多样的微生物种群,为抗菌活性先导化合物的发现提供了丰富的资源。
简要介绍了海洋真菌的特点及抗菌活性化合物的研究方法,并从海洋动物来源真菌、海藻来源真菌、海洋
沉积物来源真菌和红树林植物来源真菌等 4 个方面,综述了从 2000 年至今已报道的海洋真菌抗菌活性次级
代谢产物的研究进展,其中包括 83 个抗菌活性化合物,引用国内外文献 54 篇。
关键词:海洋真菌;次级代谢产物;抗菌活性
中图分类号: ; 文献标志码:A
Methods and advances in studies on antimicrobial substances of
marine-derived fungi
SHANG Zhuo1,2, WANG Bin-Gui1*
(1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao
266071, China; 2 Graduate School of Chinese Academy of Sciences, Beijing 100039, China)
Abstract: The antibiotic-resistance of pathogenic anisms has seriously threatened the human health
worldwide and thus it is extremely urgent to develop new antibiotics with novel structures and significant
bioactivities. The unique marine ecological environment conceives diverse munity, which provides
abundant resources for the discovery of antimicrobial pounds. This review briefly introduces the
characteristics of marine-derived fungi and the approaches of antimicrobial metabolites discovery, and summarizes
the research progress of antimicrobial secondary metabolites of marine-derived fungi of those obtained from marine
animals, algaes, mangroves as well as marine sediments. A total of 83 antimicrobial metabolites and 54 references
are included in this review, which covers the literature published since 2000.
Key words: marine-derived fungi; secondary metabolites; antimicrobial activity
抗生素(antibiotics) 是由微生物或高等动植物加剧、社会和人文的变迁都使人类的免疫力不断下
在生活过程中所产生的、具有抗病原体和干扰其他降,新的致病菌、条件致病菌和超级耐药菌不断出
细胞发育活性的一类次级代谢产物。20 世纪初期发现,这些已成为全世界所面临的严重的社会问题。
现的青霉素、链霉素、金霉素和灰黄霉素等抗生素虽然通过化学方法对现有抗生素进行结构修饰
挽救了数以百万计人的生命。然而,随着抗生素和改造可以开发出一些活性更强、毒性更小的药