文档介绍：Acquired Coagulation Disorders
Dr Mohammed Saiem Al-dahr
KAAU
Faculty of Applied Medical Sciences
dr msaiem
Acquired coagulation disorders
Objectives
Following this lecture, the student will be able to
Explain the classification of acquired disorder of haemostasis such as:
Hepatic disease, vitamin K deficiency, renal disease,
Explain the action of oral anticoagulants
Name the mon laboratory tests used to monitor oral anticoagulant therapy
List mechanisms and clinical conditions associated with DIC.
Define the three generalized clinical states of DIC
Laboratory abnormalities associated with DIC.
Identify therapies for treatment of DIC
dr msaiem
Acquired coagulation disorders
The normal haemostasis is a normal balance carefully designed so that hemorrhage arrested and inappropriate thrombosis does not occur.
Acquired disorders of haemostasis occur with many, systemic diseases, drugs, physical states pregnancy and newborns.
Diagnosis depends on;
Careful history
Physical Examination
Properly directed lab tests.
dr msaiem
Acquired coagulation disorders
The initial difficulty is to distinguish local bleeding . peptic ulcer from systemic disease.
An initial series of screening tests are performed easily and rapidly;
Platelet count + Blood film
Bleeding time (BT)
Prothrombin Time (PT)
Partial Thromboplastin Time (PTT)
Thrombin Time (TT)
Assessment of Fibrinogen
dr msaiem
Acquired coagulation disorders
If screening is suggestive, specific special investigations are performed to confirm, the diagnosis.
The acquired disorders of haemostasis that will be discussed here include the following;
Hepatic Disease
Vitamin K deficiency
Vitamin K Antagonists
Renal Disease
DIC
dr msaiem
Acquired Coagulation Disorders
Hepatic Disease
The liver is the principal site of synthesis of pro-coagulant, fibrinolytic, and coagulation inhibitory proteins.
Liver disorders present two challenges:
1-Decreased synthesis of coagulation, lysis and inhibitory proteins
2-Impaired