文档介绍：Characteristics of submucosal gastric carcinoma with lymph node metastatic disease
H J Son, S Y Song,1 S Kim,3 J H Noh,2 T S Sohn,2 D S Kim1 & J C Rhee
Presented by intern 張家維
Histopathology 2005, 46, 158–165.
Introduction
2nd mon cause of cancer deaths
East Asia and south America
Korea and Japan early detection
Early Gastric Carcinoma
Mucosa or Submucosa
5-year survival rate
Lymph node metastasis
prognosis, submucosal invasion
Introduction
Depth of submucosal layer viaries
The depth of submucosal gastric carcinoma (SMGC)
Lymph node metastasis
macroscopic appearance, location, size, tumor area, differentiation, invasion depth, submucosal vascularity, fibrosis near the tumor area
Age- and Sex- matched
Materials and methods
Sampling: 248 patients SMGC
Surgical resection
Samsung Medical Centre (Seoul, Korea)
1995/Jan.~ 2002/Oct.
Total 917 patients SMGC
124 LN metastasis (%)
Anticancer therapy X
Evidence of metastatic disease X
Materials and methods
124 SMGC with LN metastasis
124 SMGC without LN metastasis
Age- and Sex- matched
Specimens routinely examined
10% formalin
Embedded in paraffin
H & E stained
Materials and methods
Macroscopic:
Japanese Endoscopic Society Classification
Elevated, Depressed, Flat
Microscopic:
Lauren classification
Materials and methods
Depth of submucosal invasion
lens scale, distance between the
lower edge of the muscularis mucosa and
the deepest invading front of the tumor
cells
method: sm1, sm2, sm3
method: smi , sme
Materials and methods
Tumor size
Longest dimension of the tumor area
Tumor area
Longest dimension X its prependicular counterpart
Tumor vessels
vessels with a smooth muscle coat in the submucosa
Materials and methods
Statistical analysis:
Log linear model, McNemar’s test, A paired t-test, Wilcoxon’s signed rank test
P-value < statistically significant
SAS, version