细胞因子联合纹状体条件培养液定向诱导间充质干细胞体外分化为多巴胺能神经元的研究(英文).doc

文档介绍：基础医学
细胞因子联合纹状体条件培养液定向诱导间充质干细胞体外分化为
多巴胺能神经元☆
李府1,马丽霞1,张乐玲1,郑立波1,陈颖杰2,吴镇2,王世富1
bined with striatal conditioned medium to induce differentiation of mesenchymal stem cells into dopaminergic neurons in vitro
Li Fu , Ma Li-xia1, Zhang Le-ling1, Zheng Li-bo1, Chen Ying-jie2, Wu Zhen2, Wang Shi-fu1
1Pediatric Research Institute, Qilu Children’s Hospital of Shandong University, Jinan 250022, Shandong Province, China; 2Hematology Laboratory, Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Li Fu☆, Doctor, Associate chief physician, Pediatric Research Institute, Qilu Children’s Hospital of Shandong University, Jinan 250022, Shandong Province, China
lifusd@ or lifu1970@
Received: 2008-04-23
Accepted: 2008-06-30
1山东大学齐鲁儿童医院儿科医学研究所,山东省济南市 250022; 2 山东大学第二医院血液实验室,山东省济南市250033
李府☆,男,1970年生,山东省临沂市人,汉族, 2004年山东大学医学院毕业,博士,副主任医师,主要从事干细胞基础与临床研究。
lifusd@
; lifu1970@
中图分类号:
文献标识码:A
文章编号:1673-8225
(2008)43-08485-05
收稿日期:2008-04-23修回日期:2008-06-30
(54200804230013/
GW·A)
Abstract
BACKGROUND: Induction rate of bone marrow mesenchymal stem cells (BMSCs) to differentiate into dopaminergic neurons in vitro is not satisfactory.
OBJECTIVE: To explore the possibility of basic fibroblast growth factor, epidermal growth bined with striatal conditioned medium to promote directional differentiation of MSCs into dopaminergic neurons.
DESIGN, TIME AND