文档介绍：肿瘤 2012 年 2 月第 32 卷第 2 期 TUMOR Vol. 32, February 2012
DOI: .1000-
Copyright© 2012 by TUMOR
临床研究·Clinical Research
GP73在肝细胞癌诊断中的价值
, , , , , ,
梁嵘罗小玲葛莲英袁卫平岳惠芬贾保昌沈筱芸
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广西医科大学附属肿瘤医院实验研究部南宁 530021
探讨( )在肝细胞癌诊断中的价值。收集外周血血清例,其中肝
[ 摘要] 目的: GP73 Golgi protein-73 方法: 504
细胞癌例、肝硬化例、乙型病毒性肝炎例、乙型肝炎病毒携带者例、其他恶性肿瘤例、肝良性
144 50 100 84 50
肿瘤例和健康志愿者例;应用双抗体夹心酶联免疫定量测定方法和电化学发光法检测血清中和甲胎
26 50 GP73
蛋白( , )的表达水平。肝细胞癌组血清的表达水平显著高于其他各组( < );
α-fetoprotein AFP 结果: GP73 P
受试者工作特征( , )曲线设定临界值为时, 诊断肝细
receiver operating characteristic ROC GP73 64 ng/mL GP73
胞癌的灵敏度和特异度分别为和,显著高于( 和),差异有统计学意义( < );
% % AFP % % P
血清联合检测诊断肝细胞癌的灵敏度可达。血清的表达水平用于诊断肝细胞癌的灵
GP73 AFP % 结论: GP73
敏度和特异度优于,血清联合检测可提高肝细胞癌的诊断率。
AFP GP73 AFP
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[ 关键词] 癌肝细胞血清诊断 Golgi protein-73 甲胎蛋白
[中图分类号] [文献标志码] A [文章编号] 1000-7431 (2012) 02-0115-04
The diagnostic value of serum Golgi protein-73 in hepatocellular carcinoma
LIANG Rong, LUO Xiao-ling, GE Lian-ying, YUAN Wei-ping, YUE Hui-fen, JIA Bao-chang, SHEN Xiao-yun
Department of Laboratory Research, Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China
[ABSTRACT] Objective: To investigate the diagnostic value of serum Golgi protein-73 (GP73) in
hepatocellular carcinoma (HCC). Methods: The peripheral serum samples from 504 individuals were
collected, includi