文档介绍：生命科学导论论文翻译IL-23signalingenhancesTh2polarizationandregulatesallergicairwayinfammation白细胞介素发出信号增强TH2细胞极化和调节过敏通道炎症Keywords:cytokines,helperTcells,Tcelldifferentiation,allergicairwayinflammation关键词:细胞因子,辅助型T细胞,T细胞变异,monhealthprobleminde-(Th),nativeCD4TcellsdifferentiateintoaprevailingTh2effectorphenotype,andthesecellspredominantlysecretinterleukin-4(IL-4),IL-5,andIL-,thesecytokinesinducetherecruitmentoeosinophils,mastcellsandlymphocytes,hyperplasiaofsmoothmuscleandgobletcells,andairwayhyperresponsiveness,whichareoftenassociatedwithincreasedserumIgEconcentration[1-3].IL-23isamemberoftheIL--12[4].IL-posedoftheIL-12receptorβ1(IL-12Rβ1)andIL-23receptor(IL-23R)andthissubsequentlyactivatesJak2,Tyk2,andsignaltransducersandactivatorsoftranscription(STATs)1,3,4,and5[5].LikeIL-12,IL-23isprimarilysecretedbyactivatedDCs,monocytes,andmacrophages[6].IthasbeenshownthatIL-23isimportantinsomeinfammatorydiseasesincludingexperimentalautoimmuneencephalitis,collagen-inducedarthritis,andintestinalinflammation[7-9].Moreover,polymorphismsinthegeneencodingtheIL-23Rareanimpo