文档介绍：
廖伟棠,霍霞,刘伟,杨辉,纪曼辉,徐锡金
(汕头大学医学院分析细胞学实验室,广东汕头￥15041)
[摘要]目的:探讨慢性铅暴露儿童的机体氧化应激水平。方法:采用石墨炉原子吸收光谱法。检测贵屿镇118名30岁儿
童血铅浓度;ELISA免疫酶联吸附法检测尿液中8-羟基脱氧鸟苷(8-OHdG)水平。结果:贵屿镇儿童血铅均值为(±)
Ve,/dL。将血铅水平按四分位数分成4组进行统计学处理,- V.#dL组尿中8-OHdG水平比,——
V.#dL组明显增高(P<)。结论:慢性铅暴露儿童尿液中8-OHdG水平的升高。表明儿童机体处于较高的氧化应激状态,
对儿童生长发育会造成一定的伤害。
[关键词]电子垃圾;血铅;氧化应激;8-羟基脱氧鸟苷
[中图分类号]
[文献标识码]A
[文章编号](2011)01砌2翘;
Influence of Lead Exposure
on
Urine 8-Hydroxy-2'-Deoxyguanosine of Children
in
an
Electronic
Waste
Recycling Area
LIAO Wei—tang,HUO Xia,LIU Wei,YANG Hui,JI Min—hui,XU XJ-jin
(Anal#e Coqai∞ay :ay。Shanta∞矾觑戚咿Medical College,Shantou 515041,‰)
investigate the oxidative stress
blood and urine samples were collecmd from 1 18 children in cuiyu town,the blood lead level WSS determinedby酬te
furnace atomic absorption urine analysis for
8-hydroxy-2'-deoxyguanosine(8一OHdG)was
performed by
conmaercial ELISA :The blood lead level 0f 118 children
tO
lead level,the 8nldy group was
divided by med -∥dL
group,a
significant increase of 8—0一
HdG level in urine was
observed
in -
and
-
v-daL
:IJead exposure
can
affect 8-O-
HdG level in urine in
children,sugges吨an
increase of oxidative￥tre￥s level in children with
higher blood