文档介绍：毕业设计题目年产1000万瓶阿奇霉素葡萄糖注射液(100ml,,)生产车间工艺设计学院名称化学化工学院指导教师职称教授班级制药工程112班学号学生姓名2015年6月9日年产1000万瓶阿奇霉素萄葡糖注射液(100ml,,)生产车间工艺设计摘要:阿奇霉素属于大环内酯类抗生素药物,其作用机制是通过阻碍细菌转肽过程来抑制其蛋白质的生成。阿奇霉素因为在酸性环境中稳定,半衰期长,并且感染部位血药浓度高,疗效明显,安全性和稳定性方面均有保障。现已广泛应用于临床。目前,阿奇霉素国内生产工艺已日趋成熟。本次阿奇霉素葡萄糖注射液的设计在原有的生产工艺基础上进行GMP改造。具体内容包括:厂址选择,生产工艺流程,物料衡算,设备的设计与选型,车间平面布置,空调净化系统及经济效益核算等。通过设计,使厂房符合GMP规范,使生产工艺更加规范和严谨。关键词:阿奇霉素;葡萄糖注射液;车间平面布置;工艺设计Thedesignofannualoutputof10millionbottlesofazithromycinalsoglucoseinjection(10millionml,azithromycin,)productionworkshopprocess Abstract:Azithromycinbelongstothelargeringlactoneclassantibioticdrugs,itsmechanismofactionisabacteriaturntosuppresstheformationofitsproteinpeptideprocess.,azithromycinexpandingclinicalapplicationbecauseofazithromycinstabilityinacidenvironment,longhalf-life,andinfectiondrugsconcentrationishigh,thecurativeeffectisobvious,,thedomestictoitsproductiontechnologyhasbeenmature,:siteselection,productionprocess,materialbalance,theworkshoplayout,equipmentdesignandselection,airconditioningpurificationsystemandeconomicbenefitcalculation,,makethefactoryconformtotherequirementsofGMP,:Azithromycin;glucoseinjection;workshoplayout;……………………………………………………………………………………………………………………………………………………………………………………………….............................................................................................................................................................................................................................................................................................................................................................