文档介绍：Complain: right quadrant pain intermittently for 2 months.
itant : anorexia usually and diarrhea occasionally
: no special sign
Blood-RT: normal
Stool-RT: normal
Past-H: HBV infection for 20 ys.
Family-H: mother died of HBV-cirrhosis
Diagnosis ?
A case:
Male, 41 .
Hepato-Cellular Carcinoma (HCC) !
Hepato-Cellular Carcinoma (HCC)
Chang-qing Yang, MD & PhD
Tongji Hospital of Tongji University
同济大学附属同济医院杨长青
Special Terms
Hepatocellular Carcinoma (HCC) 肝细胞癌
Aflatoxin β1 黄曲霉素B1
-Fetoprotein (AFP) 甲胎球蛋白
-Glutamyl Transferase (-GT) -谷氨酰转移酶
-L-Fucosidase (ALF) -盐藻糖苷酶
Des- -Carboxy Prothrombin (D -- CP) 脱羧基凝血酶原
Hepatomegaly 肝肿大
TACE (transarterial chemoembolization ) 介入化疗
Background: HCC
mon an tumor worldwide
incidence is rising: USA /100,000
China /100,000
South Africa 60 / 100,000
in China, marginal waters > hinterland
eastern > western
one million died annually, Top 2 in tumors
Sex distribution
Male :Female = 3~5 :1 in China
Almost equal in developed countries
Age distribution
Middle aged man in predominance ( y)
It is rare in children
It rises progressively with age, although it tends to level off in the oldest age group
Etiology & Pathogenesis
Four major causal associations of HCC
The etiologic agents differs with different area
Risk factors
Major
Chronic HBV infection
Chronic HCV infection
Aflatoxin β 1
Liver fibrosis & Cirrhosis