手足口病初期炎症机制变化及临床意义.doc

文档介绍：手足口病初期炎症机制变化及临床意义
孙德宏赵桂娟徐书珍★王红臻▲
即墨市人民医院小儿科传染科▲青岛市市立医院★
摘要目的:探讨手足口病初期促炎-抗炎及免疫机制变化,为寻求早期预警敏感指标和干预措施提供理论依据。方法:检测急性期外周血象、CRP、TNF-α、IL-6及IL-10。结果:实验组均值与对照组相比较WBC、L%、CRP均有显著性差异(p<);两组促炎因子比较,TNF-α、IL-6有显著性差异(p<),抗炎因子IL-10无显著性差异(P>)结论:①手足口病早期就存在不同程度的全身炎症反应,抗炎机制尚未完全启动;②WBC、CRP、TNF-α、IL-6可作为病情加重的早期预警指标;③WBC、CRP、TNF-α、IL-6 及IL-10指标的检测可以帮助估计患儿病情和治疗效果的判断。
关键词:手足口病;血分析;CRP;细胞因子
The change and clinical significance of inflammation mechanism on early days of Hand foot mouth disease incioience
Sun Dehong ,Zhao Guijuan, Xu Shuzhen, Wang Hongzhen
Pediatrics of Jimo City People’s Hospital,Jimo 266200 China
【Abstract】Objective To explore the changes proinflammatory with antiinflammatory and immunologic of Hand foot mouth disease (HFMD),for seek early warning sensitive index and ion study to provid rationale. Methods To detected acute stage peripheral blood 、CRP、TNF-α、IL-6 and IL-10. Results The mean of experiment pared control group,Peripheral blood WBC、L%、CRP are significant difference(p<);inflammatory factor TNF-α、IL-6 are significant difference;antiinflammatory factor IL-10 no significant difference(P>);onclusion ①HFMD earlier period have had systemic inflammatory response syndrome,but antiinflammatory mechanism had not pleteness startup;②WBC、CRP、TNF-α and IL-6 can conduct and actions ic condition aggravated early waming index;③The detection of WBC, CRP, TNF-α, IL-6