瓜馥木总生物碱及3 个阿朴菲类生物碱的抑菌活性研究.doc

文档介绍：瓜馥木总生物碱及3个阿朴菲类生物碱的抑菌活性研究
傅春燕1*, 刘永辉2, 周中流3, 尹文清4, 陈凯玲4
(1. 邵阳医学高等专科学校药学系, 湖南邵阳 422000; 2. 湖南省新邵县红十字会医院, 湖南邵阳 422000; 3. 北京中医药大学中药学院,北京 100102; 4. 广西师范大学化学化工学院药用资源化学与药物分子工程教育部重点实验室, 广西桂林 541004 )
摘要:在室内用生长速率法测定了瓜馥木总生物碱及其3个阿朴菲类生物碱对甘蔗凤梨病菌、西瓜枯萎病菌、柑桔疮痂病菌、香蕉炭疽病菌、梨黑斑病菌和梨褐斑病菌的抑菌活性。结果表明:在供试质量浓度为10 mg/mL时,瓜馥木总生物碱对6种病原真菌具有很好的抑菌活性,、、、、 mg/mL;从瓜馥木总生物碱分离得到的3个阿朴菲类生物碱对6种病菌均有较高的抑菌活性,其中1,2-亚甲二氧基-N-甲氧酰基-、、、、 mg/mL。
关键词:瓜馥木总生物碱;阿朴菲类生物碱;病原真菌;抑菌活性
Inhibitory activity of the total alkaloid from Fissistigma oldhamii (Hemsl.) Merr. and its three aporphine alkaloids against pathogenic fungi
FU Chun-yan1*, LIU Yong-hui2, ZHOU Zhong-liu 3, YIN Wen-qing4, CHEN Kai-ling4
(1. Department of Pharmacy, Shaoyang Medical College, Shaoyang 422000; 2. Red Cross Hospital at Xinshao County of Hunan Province, Shaoyang 422000; 3. School of Chinese Pharmacy Beijing University of Chinese Medicine, Beijing, 100102; 4. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education of China, College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004 )
Abstract:The inhibitory activity of the total alkaloid from Fissistigma oldhamii (Hemsl.) Merr. and its three aporphine alkaloids against Thielaviopsis paradoxa (de Seynes) V. Hohnel, Fusar