急性心肌梗死病人细胞黏附分子与氧化低密度脂蛋白的变化.doc

文档介绍：急性心肌梗死病人细胞黏附分子与氧化低密度脂蛋白的变化
【摘要】目的探讨急性心肌梗死(AMI)病人细胞黏附分子与氧化低密度脂蛋白(OXLDL)的变化。方法采用ELISA法检测了69例AMI病人及45例陈旧性心肌梗死(OMI)病人血清OXLDL、血管细胞间黏附分子1(sVCAM1)、细胞间黏附分子1(sICAM1)的变化,并与39例健康人进行比较。结果 AMI组和OMI组OXLDL、sICAM1、sVCAM1水平明显增高,与对照组比较差异有显著性(F=~3 ,q=~,P<),且AMI组OXLDL、sICAM1、sVCAM1水平明显高于OMI组,差异有显著性(q=~,P<)。发病第4天死亡者和伴有室性心律失常者的OXLDL、sICAM1、sVCAM1水平明显高于存活者和无室性心律失常者(t=~,P<)。AMI病人OXLDL与sICAM1、sVCAM1水平呈正相关(r=、,P<)。结论细胞黏附分子和OXLDL参与了AMI的发生,且与病情严重程度和预后有一定关系。
【关键词】冠状动脉疾病细胞黏附分子脂蛋白类
[ABSTRACT]ObjectiveTo explore the changes of cell adhesion molecules and oxidative low density lipoprotein(OXLDL) in patients with acute myocardial infarction (AMI).MethodsBy using ELISA method,the soluble intercellular adhesion molecule1 (sICAM1),and soluble vascular cellular adhesion molecule1 (sVCAM
1) were measured in 69 AMI,45 OMI patients and 39 controls. ResultsThe concentration of OXLDL,sICAM1,and sVCAM1 in patients with AMI and OMI was higher than that in the controls (F=-3 ,q=-,P<),and even higher in AMI patients than that in OMI patients (q=-,P<). The OXLDL,sICAM1,sVCAM1 concentrations were much higher in patients with ventricular arrhythmia and the dead than that in patients without ventricular arrhythmia and survivals (t=-,P<). The OXLDL was posi