文档介绍：SLE- A Controllable, Remittable, Inflammatory Autoimmune Disease:
Data From a Long Term Follow-up Study of 1072 Lupus Patients, Shanghai RJH
Shunle Chen
Department of Rheumatology, Renji Hospital,
Shanghai Jiaotong University School of Medicine,
Shanghai, China
Background
Prognosis of lupus patients has been dramaticly improved during past decades
Thousands of SLE patients has been registered in clinic database of Dept. of Rheumatology, Shanghai Renji Hospital since 1979
To clarify the long-term e of Chinese SLE patients , a study was carried on Renji Hospital Lupus Cohort
.
Objectives
i) demographic data and quality of life
ii) morbidity and mortality rate
iii) main causes of death
Patients (Totally 1072 pts followed by Chen in his clinic)
Mean Age: (9-78) yrs
Disease duration:
Gender:
M 64 (6%), F 1008 (94%)
<10 y
≥10-<20 y
≥20-<30 y
≥30 y
497 (%)
436 (%)
121 (%)
18 (%)
Organ involvement
675 patients (63%) an involvement
LN : 378(%)
23 with CRF (21 before V1);
IBN: 41 (%) ; (36 before V1)
ILD: 115(%);
PAH: 39 (%);
NPSLE: 21 (%);
CAD: 16 (%).
Prognosis of SLE patients
1072
Alive
975 (91%)
Active
(SLEDAI>3)
219 (%)
Stable
(SLEDAI≤3)
756(%)
Died
97(9%)
Cause of Death (N=97)
No gender difference
Male: 8 ( %)
Female: 89 (%)
Main Causes of death
severe infection:%
cardio-cerebral vascular events:%
renal failure:%
SLE active: %
Others: lymphoma, a, PAH, ILD, etc.
The Prednisone usage of those stable Pts (N=756)
52 pts with drug withdrawal average yrs
Duration of drug withdraw
The stable Pts with low dose of Prednisone (N=469)
≤10mg,469 cases
=10mg,197 cases
≤, 272 cases
=, 99 cases
=5mg, 113 cases
<5mg, 8 cases