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It is impossible to draw any definite conclusions necessary to give very large doses (amounting to
from this one case, but the hypothesis that there is many millions) of living plague bacteria. In several
a selective deficiency in absorption of calcium and/or earlier experiments I have noted that with sub-
vitamin D analogous to the defective absorption of cutaneous injections of 100,000-1,000,anisms
"
principles " in other deficiency diseases, such as the as many as 40 per cent. of the inoculated rats survive.
megalocytic anaemias, bined degenera- When the dose is raised above 1,000,000 there will be
tion and pellagra, is attractive. It is probable that a mortality-rate of 90-100 per cent. Death, when
the diarrhoea was due to an over-excitability of it occurs, takes place rapidly, usually within the
the neuromuscular mechanism of the colon, for it first three or four days. On the other hand, small
disappeared, together with the other signs of doses of about anisms kill approximately
neuromuscular irritability, after the administration 100 per cent. of mice. Death takes place more
of calcium and vitamin D. The rapid disappearance of slowly-mainly in the second week after inoculation.
the pain after treatment with calcium and vitamin D It would seem that the white rat presents a consider-
is not unusual in osteomalacia, but it is difficult to ab