文档介绍：ANTIARRHYTHMIC DRUGS
抗心律失常药
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Arrhythmia:
Abnormality in
the site of origin of the impulse
the rate or regularity
the conduction
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The type of Arrhythmia:
缓慢型: 窦性心动过缓(sinus bradycardia)
房室传导阻滞(atrio-ventricular block)
快速型: 房性早搏(atrial premature contraction)
房性心动过速(atrial tachycardia,AT)
心房颤动(atrial fibrillation, AF)
心房扑动(atrial flutter, AFL)
阵发性室上性心动过速
(paroxysmal supraventricular tachycardia)
室性早搏(ventricular premature contraction)
室性心动过速(ventricular tachycardia,VT)
心室颤动(ventricular fibrillation, VF)
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The Physiological Basis of Arrhythmia
The electrophysiology of normal
cardiac rhythm
Section 1
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Rapid repolarization
Plateau
Depolarization
Final repolarization
Spontaneous depolarization
Effective
refractory period
Relative refractory period
Threshold potential
Resting membrane
potential
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Vmax: maximum upstroke slope of phase 0.
Determines conduction velocity.
refractory period
important in the genesis or suppression of certain arrhythmias
effective refractory period (ERP)
relative refractory period
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2. The electrophysiological mechanism of arrhythmias
(1) Disturbances in impulse formation:
1) Increased automaticity:
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2) Afterdepolarization and triggered:
Early afterdepolarization (EAD)
Delayed afterdepolarization (DAD)
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