文档介绍：2型糖尿病患者血脂联素与白介素18、胰岛素抵抗关系研究
陈锦凤,陈诺琦* ,杨红英,石英,吴金枝
(福建医科大学附属漳州市医院内分泌科,福建漳州 363000)
[摘要】目的:探讨2型糖尿病(T2DM)患者血脂联素与白细胞介素-18 (interleukin 18,IL-18)、胰岛素抵抗(insulin resistance,IR)关系。方法根据体重指数(BMI)将60例2型糖尿病(T2DM)患者分为超重/肥胖T2DM组(DM1组,30例)和非肥胖T2DM组(DM2组, 30例)选择姓名、年龄、BMI等相匹配的非糖尿病体检者为对照组1(C1组, 30例)和对照组2(C2组, 30例)。分别测身高、体重、血压、腰围、臀围、脂联素、IL-18、空腹血糖(FPG)、空腹胰岛素(FINS)、血脂等,以改良稳态模型评估法计算的胰岛素抵抗指数(HOMA2-IR)作为评估IR的指标。结果:(1)T2DM组血脂联素、IL-18、HOMA2-IR与对照组差异均有统计学意义(均P<)。C1组HOMA2-IR显著高于C2组,脂联素水平显著低于C2组,而IL-18差异则无统计学意义;DM1组HOMA2-IR、IL-18显著高于DM2组,脂联素显著低于DM2组;(2)T2DM组按脂联素水平分两组后发现,低脂联素组HOMA2-IR及IL-18水平显著升高。(3)T2DM组脂联素与IL-18水平明显负相关。结论:血脂联素水平是反映早期IR的一项敏感指标,可反映T2DM患者IR 的程度;脂联素水平下降可能是促发IL-18等炎症因子水平升高的始动因素。
[关键词] 糖尿病,2型;脂联素;胰岛素抵抗;白细胞介素-18
Association of serum adiponectin level with interlekin-18 and insulin resistance in type 2 diabetes CHEN Jin-feng,CHEN Nuo-qi,YANG Hong-ying,WU Jin-zhi,SHI Ying.( Department of Endocrinology,Zhangzhou Municipal Hospital,Affiliated to Fujian Medical University,Zhangzhou 363000,China)
[Abstract] Objective:To investigate the association of serum adiponectin level with serum interlekin-18(IL-18) and insulin resistance(IR) in type 2 diabetes mellitus(T2DM). Methods:60 patients with T2DM were divided into group overweight/obese T2DM (DM1,30 cases) and group non-obese T2DM (DM2,30 cases) b
ased on the body mass index(BMI). The healthy persons with the similar age,sex,and BMI to DMgr