文档介绍：CT导向125I粒子植入治疗肺癌的研究
作者:刘元伟王强庆林杰冯秀栓宋辉顾萌白云平孙香莲
【关键词】 CT
【摘要】目的:评价CT导向肺癌组织间125I粒子植入治疗肺癌的临床价值。方法:回顾性分析经病理证实的肺癌27例,其中中心型肺癌16例,周围型肺癌8例,肺癌肺转移3例。27例患者共有病灶33处, cm/病灶。CT导向下经皮穿刺肺癌组织间植入125I粒子。结果:粒子植入2个月复查:CR 20个,PR 8个,NC 4个,PD 1个,%。2个月时随访,粒子移位2例(1颗/例),粒子丢失一例(4例)。结论:CT导向肺癌组织间125I粒子植入治疗肺癌近期临床疗效显著,是一种微创,安全,高效的治疗肺癌的新方法。
【关键词】肺肿瘤;放射性同位素;介入放射学;近距离放射疗法;评价研究
【ABSTRACT】 Objective:To appraise the clinical value of the method to treat lung cancer,which plant 125I granule inside cancer with CT :There were 27 cases of lung cancer that proved by pathology examination,among them 16 cases of lung cancer were central type,8 cases were peripheral,and 3 cases are metastasis from lung cancer ’re 33 focuses in all 27 patients. The average diameter is of 125I granule were planted into the focuses after puncture operation with CT :33 focuses of 27 patients,taken further consultation with us after the 125I granule was planted 2 months later,showing obvious effect in 20 cases,showing medium effect in 8 cases,showing unapparent effect in 2 cases,and no effect only in one case,it was total % of moved in 2 cases (1 case per focus),granule not found in one case (4 pieces).Conclusion:It makes remarkable effect that planting 125I granule inside cancer with CT guiding is one kind of advanced,safe,and slight injuring method with high- efficient therapy instrument to lung cancer.
【KEY WORDS】 lung neoplasms;iodine radioisotopes;interventional radiology;brachytherapy;evaluation studies
肺癌一般恶性程度较高,临床上大部分患者发现时已失去手术机会[1],放疗和化疗因其较高的并发症发生率而令广大患者和家属所担忧,近年来经支气管动脉灌注化疗药物治疗肺癌作为一种新的治疗方法正逐渐被人们所接受,但其疗效存在一定的限度[2],笔者搜集2004年1月至2004年8月间接受CT导向下肺癌组织间125I粒子植入治疗的肺癌患者27例,就其使用方法,操作技术,安全性及近期疗效进行评价。
1 临床资料
一般资料笔者搜集2004年1月至2004年8月间接受CT导向下肺癌组织间125I粒子植入联用支气管动脉灌注化疗药物治疗的肺癌患者27例,男性19例,女性18例,年龄37岁~89岁,中位年龄71岁,其中,中心性肺癌16例,周围型肺癌8例,肺癌肺转移或肺部多发癌3例,27例患者共有病灶32个,, cm,全部病灶均经支气管镜或穿刺活检证实为肺癌,其中鳞癌16个灶,腺癌11个灶,未分化癌6个灶。