文档介绍：COSMETICS AND TOILETRIES 137
tion and consists of epidermal cell degeneration and been made to ascertain the degree of specificity of the
a moderate increase in white blood cells present in antigen molecule in such cases of leucocyte-trans-
the epidermis. Sensitization must also be disting- ferred sensitivity.
uished from anaphylactic or immediate responses. The authors have been able to use the laxative
These often follow the giving of chemical substances drug pp'-dihydroxytriphenylmethane-o--
or their conjugates with proteins by parental or oral nol (I) to ascertain which structural features of this
administration. In contrast, neither type of agent molecule are responsible for the delayed-type skin
given alone by these routes evokes contact sensitiza- reaction in patients and whether the same considera-
tion. Anaphylactic responses or contact sensitization tions apply to the sensitivity induced by leucocyte
reactions may be precipitated by the pound transfer. pounds tested were: I; pp'-
in one animal depending on the mode of administra- dihydroxyt riphenylmethane(I I) ;p-hydroxytriphenyl-
tion. However here again the 2 types of sensitization methane (III); triphenylmethane (IV); phenolphtha-
may be clearly separated. An animal showing both lein (V); pp'-dihydroxydiphenylmethane(VI); and o-
types of sensitization may pletely desensitize