文档介绍：康复训练对双侧海马梗死大鼠学忆功能的影响
【关键词】脑梗死/
Effect of rehabilitation training on function of learning and memory in rats with bilateral hippocampal infarction
LI Ling, PAN HuiJuan.
Department of Physiotherapy & Rehabilitation, Xijing Hospital, Fourth Military Medical University, Xian 710033,China
【Abstract】 AIM: To investigate the changes of learning and memory function in hippocampus CA1 region in rats with bilateral hippocampal infarction after rehabilitation training. METHODS: Thirty rats were randomly divided into two groups after infarction induced by photochemistry: rehabilitation group and braking group. The rats of rehabilitation group were given training three days after infarction while the rats of braking group were braked. The behavioral tests were performed at different times: before infarction, 3d after infarction, and 7d, 14d and 21d after training. RESULTS: The rats with infarction had decreased learning and memory pared with that before infarction. The rehabilitation group showed better score and faster recovery of learning and memory function than the braking group at different times after training. CONCLUSION: Rehabilitation training can accelerate the recovery of learning and memory function in rats with bilateral hippocampal infarction.
【Keywords】 Brain Infarction/rehabilitation; Hippocampus; learning;memory; rats
【摘要】目的: : 30只SD大鼠采用光化学诱导法制作双侧海马梗死模型,于24 h后将模型大鼠随机分为康复组和制动组,各15只,于造模3 d后开始分别给予康复训练或制动,分别在大鼠造模前、造模后3 d、康复训练后7,14和21 : 大鼠双侧海马梗死后较梗死前学忆功能下降(P<001);康复组不同时相的学忆成绩较制动组恢复快(P<005).结论: 康复训练可促进双侧海马梗死大鼠学忆功能的恢复.
【关键词】脑梗死/康复;海马;学忆;大鼠
0引言
学忆是大脑最基本也是最重要的高级神经功能之一,,众多研究表明,损毁双侧海马动物的学忆能力明显下降,对大鼠的分辨学习、防御条件反应的保持及空间习得能力都有破坏[1、2].脑缺血是危害人类健康的常见病、多发病,患者常有相应的运动、感知觉及学忆障碍最为常见持久,,康复治疗对缺血性脑梗死患者在改善感觉、运动、行为能力方面已获得明显的疗效[3,4].本实验即通过光化学法诱导的双侧海马梗死模型,观察大鼠双侧海马梗死后康复训练对学忆功能的影响.
1材料和方法
,光源为一充气氙灯,输出功率: Min