文档介绍：康复训练对大鼠脑梗死后Fos和Hsp70表达的影响
作者:李玲,袁华,牟翔,徐莉
【关键词】康复
关键词: 康复;脑梗死;基因,Fos;热休克蛋白质类70
摘要:目的研究康复训练对脑梗死大鼠大脑皮质Fos,Hsp70表达的影响. 方法采用60只SD大鼠制作脑梗死模型;1d后随机分为康复组和制动组;康复组每天给予平衡、抓握、旋转、行走等训练,制动组置于网状笼内固定,各组在1,7,14,21和28d检测Fos,Hsp70蛋白表达. 结果康复组和制动组大鼠大脑皮质出现Fos和Hsp70阳性反应神经元,康复组反应明显较制动组强,对侧较梗死侧多. 结论康复训练可激活脑梗死大鼠大脑梗死灶周围和对侧相应皮质神经元功能,促进运动功能恢复.
Keywords:rehabilitation;cerebral infarction;genes,Fos;heat shock proteins70
Abstract:AIM To study the effect of rehabilitation training on the expression of Fos and Hsp70in the cortex of cerebral infarcted Sixty SD rats were given cere-bral infarction and divided into2groups at random1d later:rehabilitation group was given balancing,grasping,rotating and walking
exercises everyday,while immobilization group was fixed in was used to intect the Fos and Hsp70expression1,7,14,21and28d after in-farction Fos-like immune reaction and Hsp70active neurons appeared in cortex of both sides.
Rehabilitation group responded stronger than the immobiliza-tion group and the contralateral cortex stronger than that around the infarction Rehabilitation training can activate the neurons around the infarction and in the contralateral cortex,and thus promote the recovery of rats’motor functions.
0 引言
脑血管意外是一类死亡率、致残率很高的疾病,随着急救水平的提高,降低了死亡率,、运动,