文档介绍：新风胶囊对类风湿关节炎患者抑郁情绪及血清皮质醇的影响
【摘要】目的观察新风胶囊对类风湿关节炎(RA)患者抑郁情绪及血清皮质醇的影响,并探讨其作用机制。方法
76例RA患者随机分成2组,治疗组40例采用新风胶囊,对照组36例采用正清风痛宁缓释片,观察2组的临床疗效、主要症状体征、生活质量积分、抑郁自评量表(SDS)标准分及血清皮质醇等指标变化。结果新风胶囊治疗组在总有效率、改善症状体征、活动性指标等方面与对照组相似,但在改善SDS标准分、脾虚症状、生活质量积分方面明显优于正清风痛宁对照组(P<<)。结论新风胶囊在取得疗效的同时,可改善RA患者抑郁情绪,提示新风胶囊调节内分泌失调、提高机体免疫功能及改善贫血是其可能性机制。
【关键词】类风湿关节炎;抑郁;血清皮质醇;新风胶囊
Abstract:Objective To observe effects of Xinfeng capsule (XFC) on depressive mood and serum cortisol in patients with rheumatoid arthritis and study its mechanism. Methods 76 RA patients were randomly divided into two groups. The treatment group (n=40) was treated with XFC, and the control group (n=36) with Zhengqing Fengtongning. The targets included clinical effects, symptom and sign, integral of quality of life, self-rating depression scale (SDS) and serum cortisol. Results The effects of XFC were similar to that of Zhengqing Fengtongning in the total effective rate, improving symptoms and sign, active index, etc. XFC was superior to Zhengqing Fengtongning in improving SDS standard score, the symptoms of splenic asthenia and quality of life (P< or P<). Conclusion XFC showed significant effects on treating RA, meanwhile it improved depressive mood and the level of cortisol. It
s mechanism is probably related with regulating endocrine disturbance, increasing immune function and improving anaemia in RA pati