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中国实验血液学杂志 Journal of Ex perimental Hematology 2004 ; 12 (6) :875 - 879 · 578 ·
文章编号(Article ID) :1009 - 2137(2004) 06 - 0875 - 05 ·综述·
人造血干细胞的免疫缺陷小鼠移植模型研究与应用
胡东,黄士昂
湖北省暨华中科技大学同济医学院附属协和医院干细胞中心,武汉 430022
摘要已有多种免疫缺陷动物被用于人造血干/ 祖细胞的检测。理想的免疫缺陷动物应具有完整的免疫缺陷,
能高效的移植人造血干/ 祖细胞,又有足够长的寿命能适于观察。通过介绍 Nude、SCID、Nod/ SCID、NOD/ SCIDβ2
2mnull等一系列免疫缺陷小鼠的遗传及免疫学特点及其在造血干细胞研究中的贡献。本文综述了小鼠移植模型的
发展,评价了免疫缺陷移植模型在造血干细胞研究中的重要性及小鼠移植模型的新进展和方向。
关键词造血干/ 祖细胞;免疫缺陷小鼠;异种移植模型
中图分类号 R332 ; R457. 7 文献标识码 A
The Immuno Def icient Mice Transplantion Models in Study of Human
Hematopoietic Stem Cells ———Review
HU Dong , HUA N G S hi A ng
Hubei Stem Cell Center , Union Hospital , Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China
Abstract A variety of immuno deficient animal models has been used in the detection of human hematopoietic stem/
progenitor cells and up to date make many remarkable contribution to the study of detectron cell biology. An ideal im
muno deficient animal should not only plete immune defects , be able to transplant human hematopoietic stem/
progenitor cells with high efficacy , but also survive long enough for observation. In this review , the development of im
muno deficient mice from nude , SCID , to NOD/ SCID etc is introduced and much attention isp