骨质疏松性骨折愈合过程中骨痂局部生物力学的改变.doc

文档介绍：骨质疏松性骨折愈合过程中骨痂局部生物力学的改变
【关键词】骨质疏松症
关键词: 骨质疏松症;骨折;弹性模量;极限强度

摘要:目的探讨骨质疏松骨折愈合过程中骨痂局部生物力学性能的变化. 方法利用SD大鼠骨质疏松胫骨骨折模型,测量了骨痂局部弹性模量和极限强度的变化. 结果骨质疏松骨折愈合过程中,弹性模量和极限强度均随着骨折愈合过程的进行而增加,在骨折后35d编织骨完全形成后,极限强度与非骨折组相比无明显差别,而弹性模量有明显差别;而两者在同一时间点与正常骨折组相比均无明显差别. 结论骨质疏松骨折骨痂局部的弹性模量及极限强度的变化模式与正常骨折骨痂相比无明显差别.

Keywords:osteoporosis;fracture;elastic modulus;maxi-mum intensity

Abstract:AIM To research the changes of the biomechanics of the local bone callus in the process of osteoporotic bone The elastic modulus and maximum in-tensity in the local callus were measured using osteoporotic tibial fracture The values of elastic mod-ulus and maximum intensity increased with the proceeding of the osteoporotic bone were significant differ-ence in the maximum intensity but not in the elastic modulus at fracture pared with the non-fracture there was no significant difference at the identical time points between two There m
ay be no sig-nificant difference in the changing model of the elastic modu-lus and the maximum intensity between the osteoporotic and normal groups.

0 引言

骨质疏松(osteoporosis,OP)后,皮质骨和松质骨的生物力学性能均发生了改变[1] :骨皮质变薄,骨弹性下降,骨脆性增加,骨小梁变得纤细,骨小梁的完整性和连续性下降,甚至发生微损害,,骨骼的支撑负重功能随之丧失,但随着骨折的愈合,结构的再生和修复,其生物力学性能也逐渐恢复[2] .然而,有关骨质疏松骨折后骨痂局部生物力学性能发生的变化,,这不仅有助于深入了解骨质疏松骨折