文档介绍：羟基喜树碱联合顺铂治疗复发小细胞肺癌临床观察
潘佳丁凯缪东王建军
河南大学淮河医院肿瘤内科(开封市 475000)
摘要:目的观察羟基喜树碱联合顺铂治疗复发小细胞肺癌( SCLC) 的疗效及毒副反应。方法选取复发小细胞肺癌患者36 例,予以顺铂75 mg /m2 第1天,羟基喜树碱6mg /m2 *d第1-5天,每21d为一周期,每个周期结束复查CT评价疗效,观察其疗效及毒副反应。结果完全缓解(CR)2例,部分缓解(PR)10例,疾病稳定(SD)13例,疾病进展(PD)11例,客观缓解率(ORR) %,疾病控制率(DCR) %,中位无进展生存期(PFS),中位生存期(MST),%。主要毒副反应为血液学毒性、恶心、呕吐。全组无毒性相关死亡。结论羟基喜树碱联合顺铂可用于治疗复发小细胞肺癌,不良反应可以耐受。
【关键词】羟基喜树碱; 顺铂; 化疗; 小细胞肺癌; 复发
Clinical observation of 10-hydroxy camptothecin and Cisplatin treatment of relapsed small cell lung cancer
PAN Jia, DING Kai,MIAO Dong,WANG Jianjun
Department of Oncology Huaihe Hospital Henan University
Kaifeng,Henan,475000,P .
Abstract Objective To observe the efficacy and toxicity of bined
10-hydroxy camptothecin with Cisplatin in relapsed small cell lung cancer( SCLC) patients. Methods A total of 36 relapsed SCLC patients received Cisplatin 75 mg /m2 and 10-hydroxy camptothecin 6mg /m2 D1-5 Days by the intravenous administration with 21 days as a cycle. Efficacy was estimated by imaging every cycle. Results For a total of 36 patients,2 patients was CR,10 patients was PR,13 patients was SD,11 patients was PD. The objective response rate( ORR) was % . The disease control rate ( DCR) was % . The median progression free survival ( PFS) was months. The mediansurvival time(MST) was 7. 9 months. One-year survival rate was %. The major toxici