文档介绍：
李柱来,王津,林媚,许秀枝,叶晓( 福建医科大学药学院,福州350004)
摘要:目的研究自制壳聚糖- 吲哚美辛微囊的药动学。方法以市售普通吲哚美辛片剂为参比通过高效液相色谱测定模型
动物家兔药时曲线。结果与普通片剂相比,,迭峰时间明显推迟,且达峰浓度降低( P<
) ;同时药物在兔体内平均驻留时间明显长于普通片( P<) ;但两制剂的AUC无差异( P>) 。结论研制的壳聚
糖一吲哚关辛微囊具有较好的缓释效果。且吸收程度与普通吲哚美辛片荆等效。
关键词:壳聚糖;吲哚美辛;微囊;药动学
中图分类号:;:1{ 文献标识码:A 文章编号:1007-7693(2008)07-0605-03
St u dy on Pha r i cs of I ndome t hac i n- Chi t osan Mi c r oca psul es
LI me di cal
Zhu— l a i ,WANG J i n,LI N Me i ,XU Xi u— z hi ,YE Xi ao(Facul t y of Phar macy,Fumn uni ver si t y,Fuj i an 3500 04,
Chi na )
ABSTRACT:OBJECTI VE To st ud y t he ph ar mae i c s of i nd omet h aci n- c hi t os an mi erocaps ules .METHODS Ta ki n g c onven·
t iona l i nd ome t haci n t abl et s as cont r o l ,and hi gh pr ef or mance l i qui d chromatogr aphy(HPLC) was us ed t o de t er mi ne dr ug concent r at i on-
t i me cu r v e in r abbi t s .pa r ed wi t h t he convent i onal t abl ets,t he s us tai ned— r el eas e i ndomet haci n— chi t osan mi c r oca psul es
ha d l onger acti on t i me in r abbi t s,and t he peak t i me Wf K' ;obvi ous l y del a yed,t he pea k concent r at i on Wf l kQ, decr eas t he AUC of
t h em wa s not di ff er ent s t at i s t i cal l y(P>) .CONCLUSI ON The pr e par ed i ndomet haci n— chi t osan mi e r ocap sul es has a bet t er $US—
t ai ned dr u g r el ease ef f ect ,a nd