文档介绍：癌胚抗原生物半衰期监测恶性肿瘤的评价
作者:刘树林,齐为民,张丽君,赵熠
【关键词】肿瘤
关键词: 肿瘤;癌胚抗原;半衰期;复发;肿瘤转移
摘要:目的观察恶性肿瘤患者血清癌胚抗原(CEA)半衰期(T
1/2 )在术后监测中的意义. 方法应用单克隆双抗体夹心酶免疫一步法分别检测治疗前、后血清CEA. 结果治疗后血清CEA预测恶性肿瘤复发或转移的敏感性,特异性和总符合率(准确度)分别为56%,82%和77%,而CEA半衰期T1/2 >15d时分别高达89%,94%和93%. 结论血清CEA T1/2 检测优于CEA测定,术后残余癌细胞越多CEA T1/2 越长,故CEA T1/2 是恶性肿瘤复发转移早期极敏感的监测指标. Significance of serum carcinoembryonic antigen bio┐logical half┐life for patients with malignant tumors
Keywords:neoplasms;carcinoembryonic antigen;half-life;recurrence;neoplasms metastasis
Abstract:AIM To study the meaning of serum carcinoem-bryonic antigen(CEA)biological half-life(T1/2 )for the pa-tients with malignant CEA contens in serum were determined by
one step double sandwich Sensitivity,specificity and accuracy of predicting malignant tumors recurrent and metastasis after treatment serum CEA levels were56%,82%,77% CEA T1/2 >15d,the sensitivity,specificity and ac-curacy were89%,94%,93% Analysis of CEA T1/2 in serum is better than serum CEA total levels more residual cancer cells ex-ist the longer CEA T1/2 CEA T1/2 is a sensitive target to predict the early-stage tumor recurrence and metas-tasis.
0 引言
自从1965年Gold和Freeman报告了CEA作为大肠癌的肿瘤标志物后,CEA已被广泛用于各种恶性肿瘤的术前分期和预后判断[1] .目前众多研究是根据治疗后CEA含量监测恶性肿瘤的复发、转移,其敏感度(%)并不理想[2] .Yos