文档介绍：BIS用于经鼻蝶垂体瘤切除术指导异氟烷吸入对麻醉恢复的影响
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【摘要】目的研究脑电双频指数(BIS)在显微镜经鼻蝶垂体瘤切除术中指导异氟烷吸入对麻醉恢复的影响。方法行显微镜经鼻蝶垂体瘤切除术患者30例,年龄18-65岁,ASAⅠ~Ⅱ级,随机分为BIS组和对照组,每组15例。所有患者采用标准麻醉诱导,%~3%异氟烷吸入和标准瑞芬太尼持续微量泵输注维持麻醉。BIS组术中调整异氟烷的浓度使BIS维持在40~60,对照组根据患者血流动力学调整异氟烷浓度。术中每5 min 记录患者BIS、吸入、呼气末异氟烷浓度等,手术结束记录自主睁眼、呼吸时间、拔管时间和达到Aldrete改良评分9~10的时间。结果与对照组相比,BIS组手术期间的BIS升高、术中异氟烷用量减少、呼气末异氟烷浓度降低,从手术结束至自主睁眼、自主呼吸和Aldrete 9~10 的时间缩短。结论 BIS指导异氟烷吸入能减少经鼻蝶垂体瘤切除术中异氟烷用量,加快患者麻醉恢复,有利于尽早进行神经系统检查。
【关键词】异氟烷;脑电描记术;垂体腺瘤;麻醉恢复期
Abstract: Objective To explore the effect of using bispectral index (BIS) in titration of isoflurane to improve early recovery of patients undergoing microscopic transsphenoid surgery for pituitary adenoma. Methods Thirty ASA Ⅰ-Ⅱpatients, aged from 18 to 65 years old, undergoing microscopic transsphenoid surgery for pituitary adenoma were randomly divided into two groups (n=15 each): BIS group and control group. Before induction, BIS sensor was applied to the forehead and connected to Aspect A2000XP BIS monitor. All patients received standard anesthetic induction drugs,and %-3% isoflurane inhalation and standard remifentanil continuing infusion with micropump was used for maintenance of anesthesia. In the BIS group, the concentration of isoflurane was titrated to keep BIS at 40-60 level during the operation. In the control group, the anesthesiologist was blinded to