CD44V6，HIF-1α，VEGF与非小细胞肺癌侵袭和转移的关系.doc

文档介绍：CD44V6,HIF-1α,VEGF与非小细胞肺癌侵袭和转移的关系
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【摘要】目的探讨CD44V6、HIF-1α、VEGF在非小细胞肺癌(NSCLC)中的表达与非小细胞肺癌侵袭和转移的关系。方法通过免疫组化的方法(SP法)测定粘附分子(CD44V6 )、血管内皮细胞生长因子(VEGF)和缺氧诱导因子(HIF-1α)在非小细胞肺癌组织中的表达情况。结果 CD44V6 、HIF-%、%%;CD44V6 、HIF-1α、VEGF蛋白表达与肿块大小、病理类型、组织分程度、淋巴结转移、临床分期密切相关,并且在非小细胞肺癌中的表达相互之间存在相关性;这3种蛋白的共表达与淋巴结转移、临床分期相关。结论 CD44V6 、HIF-1α和VEGF在NSCLC中的阳性表达与NSCLC的侵袭和转移密切相关。
【关键词】 CD44拼接异构体6 血管内皮生长因子缺氧诱导因子-1α蛋白非小细胞肺癌免疫组化染色炎性假瘤
Abstract:Objective This thesis aims to evaluate the relationship between the expression of CD44V6, HIF-1α,VEGF in non-small cell lung cancer (NSCLC ) and the behaviour of the invasion, metastasis of NSCLC. Methods The expressions of CD44V6,HIF-1
α and VEGF were detected by immunohistochemical method. Results The positive expression of CD44V6, HIF-1α,VEGF in NSCLC was demonstrated in %,% and % respectively. The expression levels of CD44V6, HIF-1α,VEGF were associated with tumor size, pathotype, histological differentiation, lymph nodal metastas,TNM stage(), and there were significant correlations among them. bined positive expression of CD44V6,HIF-1α, and VEGF was related to lymph nodal metastas, TNM stage().Conclusions The expression of CD44V6, HIF-1α,VEGF in NSCLC correlates closely with the behaviour of the invasion, metastasis of NSCLC.
Key words:CD44V6;HIF-1α; VEG