文档介绍：CK19、gal-3、HBME-1和Ret蛋白在甲状腺乳头状癌中的表达
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【摘要】目的探讨甲状腺乳头状癌中CK19、galectin-3、HBME-1和Ret的表达及其在病理诊断中的价值。方法分别采用免疫组织化学Envision法及LSAB法检测CK19、galectin-3、HBME-1和Ret在70例甲状腺乳头状癌、15例结节性甲状腺肿和40例癌旁正常滤泡中的表达。结果 CK19、galectin-3、HBME-1和Ret在乳头状癌组织的阳性率为100%(70/70)、%(68/70)、%(66/70)%(62/70),均有统计学意义()。结论 CK19、galectin-3、HBME-1和Ret在甲状腺乳头状癌中表达增加,在病理诊断中有一定价值。
【关键词】甲状腺肿瘤乳头状癌滤泡角蛋白
【Abstract】 Objective To study the expression of cytokeratins19(CK19)、galectin-3(gal-3)、HBME-1 and Ret in thyroid papillary carcinoma (TPC) and their diagnostic value. Methods 70 cases of TPC (40 cases with adjacent normal thyroid tissus) and 15 cases of nodular goiter with papillary hyperplasea were enrolled into the study. immunohistochemical staining for CK19, gal-3, HBME-1 and Ret was performed in all cases using EnVision and LSAB methods respectively. Results The positive rates for CK19, gal-3, HBME-1 and Ret in TPCs were 100%(70/70)、%(68/70)、%(66/70) and %(62/70), the differences were statistically significant(). Conclusion CK19, Gal-3, HBME-1 and Ret expressions are significantly higher in TPCs than those in benign thyroid tissue, which has certain diagnostic value.
【Key words】 Thyroid neoplasms Carcinoma papillary Follicular Keratin
甲状腺乳头状癌是最常见的甲状腺恶性肿癌。典型的甲状腺乳头状癌以其典型乳头状结构和特征性的细胞核形态,包括毛玻璃核、核沟、核内胞质包涵体等特点而易做出诊断[1],但是在日常工作中时常会遇到不典型的病例,而结节性