C-反应蛋白与老年糖尿病周围神经病变的关系.doc

文档介绍：C-反应蛋白与老年糖尿病周围神经病变的关系
(作者:___________单位: ___________邮编: ___________)
作者:王嫘蔡爽滕赞陈思娇
【摘要】目的探讨2型糖尿病(T2DM)患者血清C反应蛋白(CRP)与周围神经病变的发生是否相关。方法选择在本院住院治疗的135例T2DM患者,均予肌电图检测左右胫神经的H反射潜伏期数值,将H反射35 ms者归入有周围神经病变组(A组),H反射35 ms者归入无神经病变组(B组)。检测并比较两组的血清CRP水平、血糖水平及其他临床生化参数。结果A组CRP和HbA1c水平均明显高于B组();两组FPG和PPG水平比较无显著性差异();CRP与H反射呈正相关(r=,);HbA1c与H反射亦呈正相关(r=,)。结论长期高血糖状态是T2DM周围神经病变的最主要原因,而CRP在T2DM周围神经病变的发生发展中同样具有重要作用。
【关键词】 C反应蛋白;糖尿病;周围神经病变
【Abstract】ObjectiveTo investigate the relationship between C-reactive protein (CRP) and diabetic perineuropathy (DPN) in patients with type 2 diabetes (T2DM).Methods135 T2DM patients were collected to detect H-reflex latency values of tibial nerve by electromyogram. Patiens with H-reflex values35 ms were classified to perineuropathy group (A group), while those with H reflex values35 ms were classified to non-perineuropathy group (B group). Serum CRP level, blood sugar index values and other clinical biochemical parameters of two groups were detected levels of CRP and HbA1c of group A were significantly higher than those of group B (); but FPG and PBG levels betweenthetwo groups had no significant difference (); CRP levels was correlated positively with H reflex (r=, ); HbA1c levels was also correlated positively with H reflex (r=, ).ConclusionsLasting higher blood sugar concentration is th