EPO在老年重度慢性心力衰竭伴贫血患者中的应用.doc

文档介绍：EPO在老年重度慢性心力衰竭伴贫血患者中的应用
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作者:李天民赵九安刘军玺郑学军李瑞娟
【摘要】目的: 探讨促红细胞生成素(EPO)在重度慢性心力衰竭(chronic heart faiture,CHF )伴贫血的患者中应用的有效性。方法: ~(心功能Ⅲ~Ⅳ级)伴贫血的患者,采用前瞻性队列研究,随机分为治疗组和对照组,两组患者均给予常规抗心衰治疗,治疗组加用重组促红细胞生成素(rhEPO)注射及铁剂口服治疗,随访1年,比较两组在客观指标上的差别。结果: 两组患者在心脏射血分数(LVEF)、6min步行距离及死亡率上均有明显差异。结论: 在常规控制心衰治疗的基础上,给予EPO抗贫血干预,可延缓重度CHF伴贫血患者的病情进展,降低死亡率。
【关键词】慢性心力衰竭; 促红细胞生成素; 贫血
【ABSTRACT】 Objective: To explore the applied effectiveness of EPO in patients with serious CHF panied by : Cases were selected from patients with serious CHF panied by anemia, hospitalized between 2004 Augest and 2005 Augest, and divided at random into treatment group and control group; forward
looking filing was adopted. Two groups were both rendered regular antiheart failure treatment; control group was added injection of RhEPO and ferrous obiect; after one year followup, difference in objective indices :There was significant difference between two groups in LVEF, 6minute walking distance and death : On basis of regular treatment of antiheart failure, intervention of EPO against anemia could delay progress of serious CHF panied by anemia and even lower death rate.
【KEY WORDS】 CHF; EPO; Anemia
CHF是各种心脏病的严重阶段,尽管目前治疗CHF的水平不断提高,但随着人口老龄化的增加,冠心病及高血压的发病率逐年上升,CHF的发病率和死亡率仍呈上升趋势。因此迫切需要找到更多更好的治疗方法,以便尽可能改善CHF病人的预后。目前国外