文档介绍：HBV基因分型与病毒载量及血清标志物关系的探讨
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作者:曹军皓,赵冰红,叶彬,黄前川
【摘要】目的探讨HBV基因型与HBVDNA水平及血清标志物的相关性。方法选择125例乙肝患者血清HBVDNA复制阳性的标本分别检测HBV病毒基因分型、HBVDNA、乙肝血清标志物、谷丙转氨酶(ALT)和总胆红素(TBL)。结果 125例HBV%(89/125),%(30/125),%(3/125),%(3/125);B基因型患者血清ALT(±)U/L和TBL(±)mol/L水平高于C基因型患者ALT(±)U/L和TBL(±)mol/L,;B基因型患者血清抗%(81/89)%(7/30),;B型HBVDNA水平(±) log10copies/mL与C型(±) log10copies/mL无差异()。结论本地区HBV病毒基因型以B型为主,C型次之,B基因型对肝脏损害较C基因型重,并与HBV载量及HBeAg系统具有相关性,B基因型易发生YMDD突变。
【关键词】基因分型;HBVDNA;HBeAg/HBeAb;血清标志物
Abstract: Objective To study the relationships among HBV genotype, level of serum HBVDNA and HBV markers in patients with hepatitis B. Methods Serum samples were collected from 125 HBVDNA positive patients and HBV genotyping, HBVDNA,ALT, TBL and HBV serum markers were tested respectively. Results Of the 125 patients, %(89/125)were genotype B, %(30/125)were genotype C, %(3/125)were mixed genotype (B+C),and %(3/125)were unknown genotype. The level of ALT and TBL were significantly higher in genotype B than those in genotype C (). The positive rate of antiHBe was significantly higher in genotype B than that in genotype C ( 1). There was no significant difference of HBVDNA level between genotype B and C. Con