文档介绍：IL-8与TNF-α动态变化规律与急性脑出血的相关性分析
(作者:___________单位: ___________邮编: ___________)
[摘要] 目的:探讨TNF-α和IL-8与急性脑出血的相关性。方法:采取对比分析的方法,用酶联免疫吸附法(ELISA)检测本院神经内科30例急性脑出血住院患者发病24 h内及3、7、14 d时的血清TNF-α和IL-8水平,并与30名健康对照者进行对比分析。结果:两组血清肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)存在显著差异(P<),灶周水肿变化规律为24 h达到高峰,随后下降。观察组出血3、14 d与24 h的比较存在显著差异性。结论:急性脑出血患者TNF-α和IL-8的水平能动态反映灶周血肿、水肿的情况。
[关键词] 肿瘤坏死因子-α;白细胞介素-8;急性脑出血
IL-8 and TNF-α dynamics and correlation analysis of acute cerebral hemorrhage
HE Huifen
(The People′s Hospital of Rucheng County, Hunan Province, Rucheng424100, China)
[Abstract] Objective: To investigate the TNF-α and IL-8 and acute cerebral hemorrhage. Methods: The method parative analysis, using enzyme-linked immunosorbent assay (ELISA) detected 30 cases of hospital neurology patients hospitalized with acute onset of cerebral hemorrhage and 3, 7, 14 d 24 hours when the serum TNF-α and IL-8 level, and 30 healthy controls were analyzed. Results: Serum tumor necrosis factor (TNF-α), Interleukin-8 (IL-8) were significantly different (), change rules perifocal edema peaked at 24 hour, then decreased. Observation group, bleeding 3, 14 day and 24 hour, compared with significant differences. Conclusion: Patients with acute cerebral hemorrhage TNF-α and IL-8 levels to dynamically reflect the lesion hematoma, edema of the situation.
[Key words] Tumor necrosis factor-α; Interleukin-8; Acute